Introduction Malaria treatment may fail according to drug resistance of the infecting parasites or to bad absorption of the drug. Le Nagard H, Vincent C, Mentré F, Le Bras J. Online analysis of in vitro resistance to antimalarial drugs through nonlinear regression. Comput Methods Programs Biomed, Epub 2010. Kaddouri H, Nakache S, Houzé S, Mentré F, Le Bras J. Drug Susceptibility of Plasmodium falciparum Clinical Isolates from Africa using Plasmodium Lactate Dehydrogenase Immunodetection Assay and inhibitory Emax model for precise IC50 measurement. Antimicrobial Agents and Chemotherapy, 2006, 50: 3343-3349. The R source code of the program can be asked by email to herve.lenagard@inserm.fr. This program is a free source code distributed under the terms of the GNU General Public License as published by the Free Software Foundation; either version 2 of the License, or (at your option) any later version. A copy of the GNU General Public License can be found at: www.gnu.org/copyleft/gpl.html. |
Without any tools we find a blurred value of IC50. Moreover we do not have confident intervals for this value. The method used in the ICEstimator function is the application of a nonlinear regression on the points. ICEstimator gives an estimated value of IC50 and its confident interval.
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